Abstract < /h3 > < p class= " a-plus-plus " > Von Hippel-Lindau ( < em class= " a-plus-plus " > VHL < /em > ) is the most frequently mutated gene in clear cell renal carcinoma. Here, we identified a novel translational variant of VHL, termed VHL α, initiated from an alternative translational start site upstream and in frame with the ATG start codon. We showed that VH..."> Abstract < /h3 > < p class= " a-plus-plus " > Von Hippel-Lindau ( < em class= " a-plus-plus " > VHL < /em > ) is the most frequently mutated gene in clear cell renal carcinoma. Here, we identified a novel translational variant of VHL, termed VHL α, initiated from an alternative translational start site upstream and in frame with the ATG start codon. We showed that VH..." /> Abstract < /h3 > < p class= " a-plus-plus " > Von Hippel-Lindau ( < em class= " a-plus-plus " > VHL < /em > ) is the most frequently mutated gene in clear cell renal carcinoma. Here, we identified a novel translational variant of VHL, termed VHL α, initiated from an alternative translational start site upstream and in frame with the ATG start codon. We showed that VH..." />

A novel VHL α isoform inhibits Warburg effect via modulation of PKM splicing

< h3 class= " a-plus-plus " > Abstract < /h3 > < p class= " a-plus-plus " > Von Hippel-Lindau ( < em class= " a-plus-plus " > VHL < /em > ) is the most frequently mutated gene in clear cell renal carcinoma. Here, we identified a novel translational variant of VHL, termed VHL α, initiated from an alternative translational start site upstream and in frame with the ATG start codon. We showed that VHLα interacts with and regulates heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1), which consequently modulates pyruvate kinase transcript splicing and reprograms cellu lar glucose metabolism. Our study demonstrated that a novel VHL isoform may function as a tumor suppressor through inhibiting the Warburg effect. < /p >
Source: Tumor Biology - Category: Cancer & Oncology Source Type: research