The new total Western diet for rodents does not induce an overweight phenotype or alter parameters of metabolic syndrome in mice

In this study, we determined the impact of the total Western diet for rodents and its macro- and micronutrient components on weight gain and biomarkers of metabolic function in mice compared to a 45% fat diet-induced obesity (DIO) diet and the standard AIN93G diet. We hypothesized that mice fed the TWD would have increased body fat with indicators of metabolic syndrome similar to mice consuming the DIO diet. As expected, DIO-fed mice acquired a metabolic syndrome phenotype typified by increased energy intake, increased body weight gain, increased fat mass, higher fasting glucose, impaired glucose tolerance, and higher plasma leptin relative to the AIN93G diet.

Source: Nutrition Research - June 4, 2016 Category: Nutrition Authors: Stephany P. Monsanto, Korry J. Hintze, Robert E. Ward, Deanna P. Larson, Michael Lefevre, Abby D. Benninghoff Source Type: research