Dietary butyrylated high amylose starch reduces azoxymethane-induced colonic O6-methylguanine adducts in rats as measured by immunohistochemistry and high pressure liquid chromatography

In this study, we hypothesized that a dietary intervention that specifically delivers butyrate to the large bowel (notably butyrylated high amylose maize starch, HAMSB) would reduce colonic levels of O6MeG in rats, shortly after exposure to the DNA alkylating agent azoxymethane (AOM) when compared to a low amylose maize starch (LAMS).

Source: Nutrition Research - June 6, 2016 Category: Nutrition Authors: Richard K. Le Leu, Benjamin L. Scherer, Mark T. Mano, Jean M. Winter, Tamsin Lannagan, Richard J. Head, Trevor Lockett, Julie M. Clarke Tags: Original Research Source Type: research