The Number, Organization, and Size of Polymorphic Membrane Protein Coding Sequences as well as the Most Conserved Pmp Protein Differ within and across Chlamydia Species

Variation is a central trait of the polymorphic membrane protein (Pmp) family. The number of < i > pmp < /i > coding sequences differs between < i > Chlamydia < /i > species, but it is unknown whether the number of < i > pmp < /i > coding sequences is constant within a < i > Chlamydia < /i > species. The level of conservation of the Pmp proteins has previously only been determined for < i > Chlamydia trachomatis. < /i > As different Pmp proteins might be indispensible for the pathogenesis of different < i > Chlamydia < /i > species, this study investigated the conservation of Pmp proteins both within and across < i > C. trachomatis, < /i > < i > C. pneumoniae, < /i > < i > C. abortus, < /i > and < i > C. psittaci. < /i > The < i > pmp < /i > coding sequences were annotated in 16 < i > C. trachomatis, < /i > 6 < i > C. pneumoniae, < /i > 2 < i > C. abortus, < /i > and 16 < i > C. psittaci < /i > genomes. The number and organization of polymorphic membrane coding sequences differed within and across the analyzed < i > Chlamydia < /i > species. The length of coding sequences of < i > pmpA, < /i > < i > pmpB, < /i > and < i > pmpH < /i > was conserved among all analyzed genomes, while the length of < i > pmpE/F < /i > and < i > pmpG, < /i > and remarkably also of the subtype < i > pmpD, < /i > differed among the analyzed genomes. PmpD, PmpA, PmpH, and PmpA were the most conserved Pmp in < i > C. trachomatis, < /i > < i > C. pneumoniae, < /i > < i > C. abortus, < ...
Source: Journal of Molecular Microbiology and Biotechnology - Category: Microbiology Source Type: research