OC10_01 Analysis of Small Intramyocardial Vessels of the Heart in Chronic Cocaine Users After Sudden Death

Cocaine produces its stimulating effect by blocking the reuptake od adrenaline , noradrenaline and dopamine by the presynaptic terminals and Thus activating the sympathic nervous system Which prompts two major effects: tachycardia and coronary vasoconstriction . Finally , cocaine blocks sodium channels and HERG potassium channels, and plays a major role Thus in severely impairing the genesis and propagation of the cardiac impulse , giving rise to the arrhythmia associated with cocaine use.

Source: CVD Prevention and Control - May 31, 2016 Category: Global & Universal Authors: D. Sanch éz Quintana, C.A. Feliciano Pereira, S.G. Diaz Tags: Oral Abstract Source Type: research