Regulatory T cells: Central concepts from ontogeny to therapy

The balanced differentiation of na ïve CD4+ T cells into either pro- or anti-inflammatory fates is a central regulator of immune homeostasis, dysregulation of which can lead to inflammatory disease or cancer. Accordingly, the development of diagnostics and therapeutics to measure and modulate this balance is of great interest. In th is Review, we focus on the predominant anti-inflammatory subset, regulatory T cells (Tregs), discussing key concepts including development, function, antigen specificity and lineage stability.
Source: Transfusion Medicine Reviews - Category: Hematology Authors: Source Type: research