Cutaneous manifestations of multiple myeloma and other plasma cell proliferative disorders

Plasma cell proliferative disorders cause rare but extremely varied dermatologic manifestations that may occur as an accompaniment to established diagnoses, or may be a first clue of an underlying neoplasm in the setting of clinical suspicion. In some instances skin lesions result from aggregation of misfolded monoclonal immunoglobulins or their fragments, as in light chain –related systemic amyloidosis. On other occasions the cutaneous lesions result from deposits of malignant plasma cells or monoclonal proteins.

Source: Seminars in Oncology - February 21, 2016 Category: Cancer & Oncology Authors: Manisha Bhutani, Zainab Shahid, Alicia Schnebelen, Daisy Alapat, Saad Z. Usmani Source Type: research