Immuno-pharmacodynamics for evaluating mechanism of action and developing immunotherapy combinations
Immunotherapy has become a major modality of cancer treatment, with multiple new classes of immunotherapeutics recently entering the clinic and obtaining market approval from regulatory agencies. While the promise of these therapies is great, so is the number of possible combinations not only with each other but also with small molecule therapeutics. Furthermore, the observation of unusual dose-response relationships suggests a critical dependency of drug effectiveness on the dosage regimen (dose and schedule).
Source: Seminars in Oncology - Category: Cancer & Oncology Authors: Ralph E. Parchment, Andrea Regier Voth, James H. Doroshow, Jay A. Berzofsky Source Type: research