Activation of GPER suppresses epithelial mesenchymal transition of triple negative breast cancer cells via NF- κB signals

The targeted therapy for triple-negative breast cancer (TNBC) is a great challenge due to our poor understanding on its molecular etiology. In the present study, our clinical data showed that the expression of G-protein coupled estrogen receptor (GPER) is negatively associated with lymph node metastasis, high-grade tumor and fibronectin (FN) expression while positively associated with the favorable outcome in 135 TNBC patients. In our experimental studies, both the in  vitro migration and invasion of TNBC cells were inhibited by GPER specific agonist G-1, through the suppression of the epithelial mesenchymal transition (EMT).

Source: Molecular Oncology - January 17, 2016 Category: Cancer & Oncology Authors: Zhuo-Jia Chen, Wei Wei, Guan-Min Jiang, Hao Liu, Wei-Dong Wei, Xiangling Yang, Ying-Min Wu, Huanliang Liu, Chris K.C. Wong, Jun Du, Hong-Sheng Wang Source Type: research