IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma

Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. Dysregulation of SOCS protein expression in cancers can be one of the mechanisms that maintain STAT activation, but this mechanism is still poorly understood in oral squamous cell carcinoma (OSCC). Here, we report that SOCS2 protein is significantly downregulated in OSCC patients and its levels are inversely correlated with miR-424-5p expression.

Source: Molecular Oncology - March 21, 2016 Category: Cancer & Oncology Authors: Hsuan-Yu Peng, Shih-Sheng Jiang, Jenn-Ren Hsiao, Michael Hsiao, Yuan-Ming Hsu, Guan-Hsun Wu, Wei-Min Chang, Jang-Yang Chang, Shiow-Lian Catherine Jin, Shine-Gwo Shiah Source Type: research