Novel sesquiterpene lactone analogues as potent anti-breast cancer agents

In this study, fifty-eight ester derivatives (DETDs) with a novel sesquiterpene dilactone skeleton were organically synthesized from a bioactive natural product deoxyelephantopin (DET). Among them, DETD-35 showed potent antiproliferative activities against a panel of breast cancer cell lines including TNBC cell line MDA-MB-231, without inhibiting normal mammary cells M10.

Source: Molecular Oncology - March 23, 2016 Category: Cancer & Oncology Authors: Kyoko Nakagawa-Goto, Jo-Yu Chen, Yu-Ting Cheng, Wai-Leng Lee, Munehisa Takeya, Yohei Saito, Kuo-Hsiung Lee, Lie-Fen Shyur Source Type: research