Global re-wiring of p53 transcription regulation by the hepatitis B virus X protein

The tumour suppressor p53 is a central player in transcription regulation and cell fate determination. By interacting with p53 and altering its sequence-specific binding to the response elements, the hepatitis B virus X protein (HBx) was reported to re-direct p53 regulation of some genes.

Source: Molecular Oncology - May 31, 2016 Category: Cancer & Oncology Authors: Cheryl Chan, Thomas Thurnherr, Jingbo Wang, Xavier Gallart-Palau, Siu Kwan Sze, Steve Rozen, Caroline G. Lee Source Type: research