Inflammation influences steroid hormone receptors targeted by progestins in endometrial stromal cells from women with endometriosis

Endometriosis is an estrogen-dependent disease defined by the presence of endometrial glands and stroma outside the uterine cavity, affecting up to 15% of women during reproductive age (Giudice and Kao, 2004) and linked to pelvic pain and subfertility (McKinnon et al., 2015; Schliep et al., 2015; de Ziegler et al., 2010). The growth of ectopic lesions stimulates an infiltration of immune cells (Halme et al., 1983; Hornung et al., 2001) and the subsequent cytokine production creates a positive feedback loop that further stimulates inflammation from endometriotic cells (Bersinger et al., 2008, 2011).

Source: Journal of Reproductive Immunology - June 16, 2016 Category: Allergy & Immunology Authors: Giovanni Grandi, Michael D. Mueller, Andrea Papadia, Vida Kocbek, Nick A. Bersinger, Felice Petraglia, Angelo Cagnacci, Brett McKinnon Source Type: research