Ovine trophoblasts express cathelicidin host defence peptide in response to infection

Cationic host defence peptides (CHDP) are a diverse group of evolutionary conserved peptides with a broad range of antimicrobial and immunomodulatory functions (Brogden et al., 2003; Zasloff, 2002; Barlow et al., 2014). Increased expression and release of CHDP is an important part of the innate immune response following detection of infection via recognition of pathogen-associated molecular patterns (PAMP) through pattern recognition receptors (PRR) such as the Toll-like receptors (TLR) and nucleotide-binding oligomerisation domain (NOD) receptors (NOD-like receptors or NLRs) (Ganguly et al., 2009; Lande et al., 2007; Rietdijk et al., 2008).

Source: Journal of Reproductive Immunology - June 20, 2016 Category: Allergy & Immunology Authors: Christopher Coyle, Nick Wheelhouse, Maxime Jacques, David Longbottom, Pavel Svoboda, Jan Pohl, W. Colin Duncan, Michael T. Rae, Peter G. Barlow Source Type: research