Diabetic pregnancy activates the innate immune response through TLR5 or TLR1/2 on neonatal monocyte

Maternal diabetes during pregnancy is well known to cause perinatal morbidity and mortality in offspring (Wendland et al., 2012; Mitanchez et al., 2014; Gabbe and Graves, 2003). Poorly controlled diabetes during the early weeks of gestation increases the rates of spontaneous abortion and major congenital malformations, including atrial septal defect, anencephaly, sacral agenesis, and renal agenesis (Gabbe and Graves, 2003). In the second trimester, maternal hyperglycemia causes fetal hyperinsulinemia and fetal overgrowth, leading to a high risk of intrauterine fetal death during the last 4 –6 weeks of gestation (Gabbe and Graves, 2003).

Source: Journal of Reproductive Immunology - June 21, 2016 Category: Allergy & Immunology Authors: Sakika Yanai, Daisuke Tokuhara, Daisuke Tachibana, Mika Saito, Yuko Sakashita, Haruo Shintaku, Masayasu Koyama Source Type: research