The relationship of seminal transforming growth factor- β1 and interleukin-18 with reproductive success in women exposed to seminal plasma during IVF/ICSI treatment

It has become increasingly evident that the physiological changes at implantation are associated with interaction between the female reproductive tract and seminal plasma (SP). Previous studies have shown that SP deposition in the female reproductive tract induces active inflammatory response required to accommodate pregnancy in several animal species (Robertson et al., 1996; O ’Leary et al., 2004) and humans (Sharkey et al., 2012a). Seminal plasma is a key factor involved in the generation of maternal-fetal immune tolerance, which is essential for a successful pregnancy (reviewed by Schjenken and Robertson, 2015).

Source: Journal of Reproductive Immunology - July 4, 2016 Category: Allergy & Immunology Authors: Marina A. Nikolaeva, Alina A. Babayan, Elena O. Stepanova, Veronika Y. Smolnikova, Elena A. Kalinina, Nelson Fern ández, Lubov V. Krechetova, Ludmila V. Vanko, Gennady T. Sukhikh Source Type: research