p53 mutations promote proteasomal activity

Nature Cell Biology 18, 833 (2016). doi:10.1038/ncb3392 Authors: Moshe Oren & Eran Kotler p53 mutations occur very frequently in human cancer. Besides abrogating the tumour suppressive functions of wild-type p53, many of those mutations also acquire oncogenic gain-of-function activities. Augmentation of proteasome activity is now reported as a common gain-of-function mechanism shared by different p53 mutants, which promotes cancer resistance to proteasome inhibitors.
Source: Nature Cell Biology - Category: Cytology Authors: Tags: News and Views Source Type: research