Computer-aided design, structural dynamics analysis, and in vitro susceptibility test of antibacterial peptides incorporating unnatural amino acids against microbial infections

Infectious diseases caused by new or previously unrecognized microorganisms are a major problem worldwide. Although the term became part of the journalist's lexicon in the 1990s, emerging infectious diseases have long been recognized as an important outcome of host –pathogen evolution. Because infections may have severe public health consequences, they are a focus of both the popular press and the scientific research [1]. In the past 70 years, antibiotics have been essential in the fight against infectious diseases and have been a contributing factor in the rise in life expectancy.

Source: Computer Methods and Programs in Biomedicine - July 5, 2016 Category: Bioinformatics Authors: Yan Wang, Yong-Jian Yang, Ya-Na Chen, Hong-Yu Zhao, Shuai Zhang Source Type: research