Empirical search for factors affecting mean particle size of PLGA microspheres containing macromolecular drugs

Poly(lactic-co-glycolic acid) (PLGA) is one of the most attractive polymers used to manufacture many drug formulations, mainly due to its satisfactory safety profile and its ability to modify the drug dissolution profile for controlled-release formulations [1]. As an FDA-approved polymer, PLGA has been studied as a delivery vehicle for unstable active pharmaceutical ingredients (API) such as proteins, peptides, RNA, and DNA [2,3,4].

Source: Computer Methods and Programs in Biomedicine - July 5, 2016 Category: Bioinformatics Authors: Jakub Szl ęk, Adam Pacławski, Raymond Lau, Renata Jachowicz, Pezhman Kazemi, Aleksander Mendyk Source Type: research