Extracranial injections of botulinum neurotoxin type A inhibit intracranial meningeal nociceptors responses to stimulation of TRPV1 and TRPA1 channels: Are we getting closer to solving this puzzle?

This study demonstrates that extracranial administration of BoNT-A suppresses meningeal nociceptors’ responses to stimulation of their intracranial dural receptive fields with capsaicin and mustard oil. The findings suggest that surface expression of TRPV1 and TRPA1 channels in dural nerve endings of meningeal nociceptors is reduced seven days after extracranial administration of BoNT-A. In the context of chronic migraine, reduced sensitivity to molecules that activate meningeal nociceptors through the TRPV1 and TRPA1 channels can be important for BoNT-A’s ability to act as a prophylactic.

Source: Cephalalgia - July 21, 2016 Category: Neurology Authors: Zhang, X., Strassman, A. M., Novack, V., Brin, M. F., Burstein, R. Tags: Original Articles Source Type: research