New prospects for targeting telomerase beyond the telomere

Nature Reviews Cancer 16, 508 (2016). doi:10.1038/nrc.2016.55 Authors: Greg M. Arndt & Karen L. MacKenzie Telomerase activity is responsible for the maintenance of chromosome end structures (telomeres) and cancer cell immortality in most human malignancies, making telomerase an attractive therapeutic target. The rationale for targeting components of the telomerase holoenzyme has been strengthened by accumulating evidence indicating that these molecules
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research