Blood-Brain Barrier Dysfunction as a Hallmark Pathology in Chronic Traumatic Encephalopathy

This report represents the first description of BBB dysfunction in a pathologically proven CTE case and suggests a vascular component in the postconcussion cascade of events that may ultimately lead to development of a progressive degenerative disorder. BBB dysfunction may represent a correlate of neural dysfunction in live subjects suspected of being at risk for development of CTE.

Source: Journal of Neuropathology and Experimental Neurology - June 15, 2016 Category: Neurology Authors: Doherty, C. P., OKeefe, E., Wallace, E., Loftus, T., Keaney, J., Kealy, J., Humphries, M. M., Molloy, M. G., Meaney, J. F., Farrell, M., Campbell, M. Tags: Original Articles Source Type: research