On the synthesis of cyclodextrin –peptide conjugates by the Huisgen reaction

We present here results of the synthesis of model conjugates formed between CDX and representative peptides by click chemistry. Notably, bis‐conjugation of peptides onto a unique scaffold promotes α‐helix formation. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd.

Bis‐coupling of peptide to α‐cyclodextrin by the Huisgen reaction was reported provided long enough linker was used. The resulting conjugates display a propensity to form α‐helix in water.

Source: Journal of Peptide Science - July 21, 2016 Category: Biochemistry Authors: R émy Lartia, Christopher K. Jankowski, Sébastien Arseneau Tags: Rapid Communication Source Type: research