Chemosensitivity enhancement toward arsenic trioxide by inhibition of histone deacetylase in NB4 cell line

Conclusion
The combination of vorinostat and ATO inhibited cell proliferation, induced apoptosis, and enhanced the chemosensitivity of NB4 cells. The mechanism might be associated with increasing histone acetylation levels as well as downregulation of the Akt signalling pathway.

Source: Journal of International Medical Research - July 21, 2016 Category: Research Authors: Li, X., Guan, X., Li, F., Chen, Y., Li, N. Tags: Research Reports Source Type: research