Family ‐Based Rare Variant Association Analysis: A Fast and Efficient Method of Multivariate Phenotype Association Analysis

In this report, we describe one such implementation: the multivariate family‐based rare variant association tool (mFARVAT). mFARVAT is a quasi‐likelihood‐based score test for rare variant association analysis with multiple phenotypes, and tests both homogeneous and heterogeneous effects of each variant on multiple phenotypes. Simulation results show that the proposed method is generally robust and efficient for various disease models, and we identify some promising candidate genes associated with chronic obstructive pulmonary disease. The software of mFARVAT is freely available at http://healthstat.snu.ac.kr/software/mfarvat/, implemented in C++ and supported on Linux and MS Windows.
Source: Genetic Epidemiology - Category: Epidemiology Authors: Tags: Research Article Source Type: research