Identification of genome ‐wide selection signatures in the Limousin beef cattle breed

Summary
The study is aimed at identifying selection footprints within the genome of Limousin cattle. With the use of Extended Haplotype Homozygosity test, supplemented with correction for variation in recombination rates across the genome, we created map of selection footprints and detected 173 significant (p < 0.01) core haplotypes being potentially under positive selection. Within these regions, a number of candidate genes associated inter alia with skeletal muscle growth (GDF15, BMP7, BMP4 and TGFB3) or postmortem proteolysis and meat maturation (CAPN1 and CAPN5) were annotated. Noticeable clusters of selection footprints were detected on chromosomes 1, 4, 8 and 14, which are known to carry several quantitative trait loci for growth traits and meat quality. The study provides information about the genes and metabolic pathways potentially modified under the influence of directional selection, aimed at improving beef production characteristics in Limousin cattle.

Source: Journal of Animal Breeding and Genetics - November 25, 2015 Category: Genetics & Stem Cells Authors: A. Gurgul, T. Szmato ła, K. Ropka‐Molik, I. Jasielczuk, K. Pawlina, E. Semik, M. Bugno‐Poniewierska Tags: Original Article Source Type: research