CD36 deficiency among South ‐East Asian populations

Immune‐mediated thrombocytopenia is commonly caused by platelet‐reactive antibodies mostly against polymorphic structures residing on platelet glycoproteins such as human leucocyte antigen and human platelet antigen (HLA class I and HPA). In the Japanese population, some individuals do not express CD36 (CD36null also known as Naka) on the cell surface. Immunization of these individuals can lead to the development of CD36 isoantibodies (anti‐Naka) which play a role in the mechanism of platelet transfusion refractoriness, post‐transfusion purpura and fetal/neonatal alloimmune thrombocytopenia. Until today, however, little is known about the clinical relevance of CD36 deficiency and CD36 isoantibodies among other South‐East Asian populations. Therefore, multinational study was organised under the aegis of the ISBT to study the distribution of CD36 deficiency in this region.
Source: ISBT Science Series - Category: Hematology Authors: Tags: Special Issue Source Type: research