Odleg łe wyniki i analiza przyczyn niepowodzeń u chorych na raka krtani napromienianych konwencjonalnie i schematem przyspieszonego frakcjonowania w latach 1995–1998

Publication date: November–December 2014 Source:Otolaryngologia Polska, Volume 68, Issue 6 Author(s): Zbigniew Szutkowski, Andrzej Kawecki, Andrzej Jarząbski The clinical material consists of 217 patients with squamous cell carcinoma in supraglottic and glottic larynx in clinical stage T1–3N0M0 irradiated radically in Warsaw Oncology Centre in 1995–1998. All patients were treated with Co-60, according to two schedules of fractionation, with maintenance of the consistent therapeutic protocol. The same team of doctors worked on the treatment of patients and on the follow-up as well. The clinical material is a part of a three-phased clinical trial KBN 0295. In the course of observation, the progression of cancer was not observed in 157 patients, among whom, 66% were treated conventionally and 79% with accelerated fractionation method. 60 cases of loco-regional recurrences were noted, among which 55 were regional. The majority of failure cases was observed until the 30th of the month after the radiotherapy ended. In conventional fractionation treatment, recurrences in T1 were 8/31 (26%), in T2 22/59 (37%) and in T3 8/20 (40%). In patients treated with AF, recurrences were T1 5/39 (13%), T2 15/55 (27%) and T3 2/13 (15%) respectively. The percentage of primary site tumour recurrences for each localization and kind of treatment was analysed. In CF 28/78 (37%) of glottic tumour recurrences and 10/34 (29%) of supraglottic tumour, recurrences were observed. In AF, 12/7...
Source: Otolaryngologia Polska - Category: ENT & OMF Source Type: research