Synthesis and Anti ‐Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene‐1,4‐diones

A series of new sulfanyltriazolylnaphthalenols (10a–f and 13a–f) and sulfanyltriazolylnaphthalene‐1,4‐diones (14a–f) were synthesized and evaluated against a panel of cancer cell lines. Among the tested compounds, 10b and 10d showed the best anti‐proliferative activity with GI50 values ranging from 2.72 to 10 and 3.13 to 13.1 µM, respectively, in several of the tumor cell lines tested. Compound 10d is highly selective toward leukemia cell lines and can be regarded as a good model for the development of new anti‐leukemic agents.

New sulfanyltriazolylnaphthalenols and sulfanyltriazolylnaphthalene‐1,4‐diones were evaluated against a panel of cancer cell lines. Two of the tested compounds (10b and 10d) showed high anti‐proliferative activity with GI50 values in the range of 2.72–10 and 3.13–13.1 μM, respectively. 10d is highly selective toward leukemia cells, providing a good model for the development of new anti‐leukemic agents.

Source: Archiv der Pharmazie - July 11, 2016 Category: Drugs & Pharmacology Authors: Ibrahim Chaaban, El Sayeda M. El Khawass, Heba A. Abd El Razik, Nehad S. El Salamouni, Mariano Redondo ‐Horcajo, Isabel Barasoain, José Fernando Díaz, Jari Yli‐Kauhaluoma, Vânia M. Moreira Tags: Full Paper Source Type: research