Trisomy 8 in pediatric acute myeloid leukemia: A NOPHO ‐AML study

In conclusion, +8 is one of the most common cytogenetic aberrations in pediatric AML. Trisomy 8 positive AML is a heterogeneous group and the majority of cases have additional cytogenetic aberrations. Patients with +8 alone differed from patients with +8 other and were associated with older age, FAB M2, and FLT3‐ITD aberrations. There were no differences in survival despite the more frequent occurrence of FLT3‐ITD in +8 alone. © 2016 Wiley Periodicals, Inc.

Source: Genes, Chromosomes and Cancer - June 22, 2016 Category: Cancer & Oncology Authors: Anne Cathrine Lund Laursen, Julie Damgaard Sandahl, Eigil Kjeldsen, Jonas Abrahamsson, Peter Asdahl, Shau ‐Yin Ha, Jesper Heldrup, Kirsi Jahnukainen, Ólafur G. Jónsson, Birgitte Lausen, Josefine Palle, Bernward Zeller, Erik Forestier, Henrik Hasle Tags: Research Article Source Type: research