Correlation of Subjective Effects with Systemic Opioid Exposure from Fixed ‐Dose Combinations of Oxycodone/Acetaminophen in Recreational Users of Prescription Drugs

ConclusionImmediate‐release/extended‐release oxycodone/acetaminophen produced lower oxycodone Cmax and longer tmax than immediate‐release oxycodone/acetaminophen. Lower oxycodone concentrations, particularly at earlier time points, were strongly correlated with lesser positive subjective drug effects.

Source: Pain Medicine - August 24, 2015 Category: Anesthesiology Authors: Terri L. Morton, Krishna Devarakonda, Kenneth Kostenbader, Jeannie Montgomery, Thomas Barrett, Lynn Webster Tags: Original Source Type: research