This Suboxone Doesn ’t Work!

Today on SuboxForum people were writing about their experiences with different buprenorphine formulations.  Doctors occasionally have patients who prefer brand medications over generics, but buprenorphine patients push brand-loyalty to a different level.  The current thread includes references to povidone and crospovidone, compounds included in most medications to improve bioavailability.  Some forum members suggested that their buprenorphine product wasn’t working because of the presence of crospovidone or povidone.  Others shared their experiences with different formulations of buprenorphine and questioned whether buprenorphine products are interchangeable, and  whether buprenorphine was always just buprenorphine, or whether some people respond better to one product or another. My comments, including my observations about patient tolerance of specific buprenorphine products, are posted below. Just to get some things straight about povidone and crospovidone (which is just another synthetic formulation of povidone),  both compounds are NEVER absorbed, by anyone.   They are part of a group of compounds called ‘excipients’, and are included in many medications to help with their absorption.  They act as ‘disintegrants’– meaning they allow the medication to ‘unclump’ and dissolve in liquids, such as saliva or intestinal secretions. Molecules tend to clump together, sometimes into crystals, sometimes into other shapes.  A...
Source: Suboxone Talk Zone - Category: Addiction Authors: Tags: Addiction Buprenorphine pharmacology Psychodynamics side effects Suboxone Withdrawal exipient opioid dependence povidone zubsolv Source Type: blogs