Sustained activation of mTORC1 in macrophages increases AMPK α-dependent autophagy to maintain cellular homeostasis

The mechanistic target of rapamycin complex 1 (mTORC1) is a well-conserved serine/threonine protein kinase that controls autophagy as well as many other processes such as protein synthesis, cell growth, and me...

Source: BMC Biochemistry - July 7, 2016 Category: Biochemistry Authors: Hongjie Pan, Xiao-ping Zhong and Sunhee Lee Source Type: research