Further observations on the behavioral and neural effects of bone marrow stromal cells in rodent pain models

Conclusions Collectively, the present work adds convergent evidence supporting the use of BMSCs in pain control. As PKC activity related to N-methyl-D-aspartate receptor activation is critical in opioid tolerance, these results help to understand the mechanisms of BMSC-produced long-term antihyperalgesia, which requires opioid receptors in rostral ventromedial medulla and apparently lacks the development of tolerance.
Source: Molecular Pain - Category: Molecular Biology Authors: Tags: Research Article Source Type: research