Intact subepidermal nerve fibers mediate mechanical hypersensitivity via the activation of protein kinase C gamma in spared nerve injury

Conclusions From results obtained in this study, we strongly recommend that the intact SENFs persistently increase PKC activation and mTOR-dependent PKC synthesis participate in the initiation and maintenance of mechanical hypersensitivity in spared nerve injury, which represents as a novel insight into the therapeutic strategy of pain in the periphery.

http://mpx.sagepub.com/cgi/content/abstract/12/0/1744806916656189?rss=1

Source: Molecular Pain - June 12, 2016 Category: Molecular Biology Authors: Ko, M.-H., Yang, M.-L., Youn, S.-C., Lan, C.-T., Tseng, T.-J. Tags: Research Article Source Type: research