Characterization of methadone as a {beta}-arrestin-biased {mu}-opioid receptor agonist

Conclusions These results suggest that methadone may, at least partly, produce its pharmacological effect as a β-arrestin-biased µ-opioid receptor agonist, similar to fentanyl, and NMDA receptor blockade is not the main contributor to the pharmacological profile of methadone.

http://mpx.sagepub.com/cgi/content/abstract/12/0/1744806916654146?rss=1

Source: Molecular Pain - June 16, 2016 Category: Molecular Biology Authors: Doi, S., Mori, T., Uzawa, N., Arima, T., Takahashi, T., Uchida, M., Yawata, A., Narita, M., Uezono, Y., Suzuki, T., Narita, M. Tags: Research Article Source Type: research