Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons: Mechanisms underlying hypoalgesia in Buruli ulcer

Conclusion
Mycolactone induces toxic effects in DRG neurons, leading to impaired nociceptor function, neurite degeneration, and cell death, resembling the cutaneous hypoalgesia and nerve damage in individuals with M. Ulcerans infection.

Source: Molecular Pain - June 19, 2016 Category: Molecular Biology Authors: Anand, U., Sinisi, M., Fox, M., MacQuillan, A., Quick, T., Korchev, Y., Bountra, C., McCarthy, T., Anand, P. Tags: Research Article Source Type: research