Peripheral nerve injury induces loss of nociceptive neuron-specific G{alpha}i-interacting protein in neuropathic pain rat

Conclusion Our results show that GINIP is predominantly expressed by small nonpeptidergic nociceptive neurons and that nerve injury triggers loss of GINIP expression. Signal transduction roles of GINIP may be diverse as it colabeled with various subgroups of nociceptive neurons. Future studies may investigate details of the signaling mechanism engaged by GINIP, as well as the pathophysiological significance of lost expression of GINIP in neuropathic pain.
Source: Molecular Pain - Category: Molecular Biology Authors: Tags: Research Article Source Type: research