A cell-permeant peptide corresponding to the cUBP domain of USP5 reverses inflammatory and neuropathic pain

Conclusions Our findings reveal a crucial region in the cUBP domain of USP5 that is important for substrate recognition and binding to the III-IV linker of Cav3.2 channels. Targeting the interaction of this region with the Cav3.2 channel can be exploited as the basis for therapeutic intervention into inflammatory and neuropathic pain.

http://mpx.sagepub.com/cgi/content/abstract/12/0/1744806916642444?rss=1

Source: Molecular Pain - April 28, 2016 Category: Molecular Biology Authors: Garcia-Caballero, A., Gadotti, V. M., Chen, L., Zamponi, G. W. Tags: Research Article Source Type: research