In Vivo Efficacy of a "Smart" Antimicrobial Implant Coating

Conclusions:
The PEG-PPS coating provides a promising approach to preventing periprosthetic infection. This polymer is novel in that it combines both passive and active antibiotic-release mechanisms. The tigecycline-based coating outperformed the vancomycin-based coating in this study.

Clinical Relevance:
PEG-PPS polymer provides a controlled, "smart" local delivery of antibiotics that could be used to prevent postoperative implant-related infections.

Source: JBJS - July 19, 2016 Category: Orthopaedics Authors: Stavrakis, A. I., Zhu, S., Hegde, V., Loftin, A. H., Ashbaugh, A. G., Niska, J. A., Miller, L. S., Segura, T., Bernthal, N. M. Tags: Basic Science, Infection Scientific Articles Source Type: research