Bone Marrow Mesenchymal Stem Cell-Based Engineered Cartilage Ameliorates Polyglycolic Acid/Polylactic Acid Scaffold-Induced Inflammation Through M2 Polarization of Macrophages in a Pig Model

This study demonstrated that bone marrow mesenchymal stem cell (BMSC)-based engineered cartilage could suppress inflammation by increasing M2 polarization of macrophages, resulting in better tissue survival in a pig model. Additionally, the effect of BMSC-based cartilage on the phenotype conversion of macrophages was further studied through an in vitro coculture system. This study could provide further support for the regeneration of cartilage engineering in immunocompetent animal models and provide new insight into the interaction of tissue-engineered cartilage and macrophages.

Source: Stem Cells Translational Medicine - July 19, 2016 Category: Stem Cells Authors: Ding, J., Chen, B., Lv, T., Liu, X., Fu, X., Wang, Q., Yan, L., Kang, N., Cao, Y., Xiao, R. Tags: Tissue Engineering and Regenerative Medicine, Mesenchymal Stem Cells Source Type: research