Human Umbilical Cord-Derived Mesenchymal Stromal Cells Improve Left Ventricular Function, Perfusion, and Remodeling in a Porcine Model of Chronic Myocardial Ischemia

This study finds that umbilical cord-derived mesenchymal stromal cells transplanted by intracoronary delivery combined with two intravenous administrations was safe and could significantly improve left ventricular function, perfusion, and remodeling in a large-animal model of chronic myocardial ischemia, which provides a new choice for the no-option patients. In addition, this study used clinical-grade mesenchymal stem cells with delivery and assessment methods commonly used clinically to facilitate further clinical transformation.

Source: Stem Cells Translational Medicine - July 19, 2016 Category: Stem Cells Authors: Liu, C.-B., Huang, H., Sun, P., Ma, S.-Z., Liu, A.-H., Xue, J., Fu, J.-H., Liang, Y.-Q., Liu, B., Wu, D.-Y., Lu, S.-H., Zhang, X.-Z. Tags: Cord Blood Stem Cells, Fetal and Neonatal Stem Cells Source Type: research