Genetic variations of phenprocoumon metabolism in patients with ventricular assist devices [TRANSPLANTATION AND MECHANICAL CIRCULATORY SUPPORT]

CONCLUSIONS VKORC polymorphism affects PC dosage in the initiation as well as the maintenance phase. High rates of bleeding complications and thromboembolic events were found at the beginning of PC therapy in VAD patients. Therefore, a genotype-guided dosage algorithm might be useful in VAD patients.
Source: European Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: History, Peripheral vascular TRANSPLANTATION AND MECHANICAL CIRCULATORY SUPPORT Source Type: research