Transcriptomic analyses of Hand2 transgenic embryos

Publication date: September 2016 Source:Genomics Data, Volume 9 Author(s): Noriko Funato, Hiroki Kokubo, Yumiko Saga In this article, we further provide the data generated for the previously published research article “Specification of jaw identity by the Hand2 transcription factor.” To better understand the downstream genes of the basic helix-loop-helix transcription factor Hand2, we generated double-transgenic mice (Hand2 NC ) by intercrossing CAG-floxed CAT-Hand2 mice with Wnt1-Cre mice for conditional activation of Hand2 expression in the neural crest. Altered expression of Hand2 induces transformation of the upper jaw to the lower jaw in Hand2 NC mutant mice. This data article provides Tables detailing the differentially expressed genes between wild-type and Hand2 NC mutant embryos. The raw array data of our transcriptomes as generated using Affymetrix microarrays are available on the NCBI Gene Expression Omnibus (GEO) browser (Reference number GSE75805).

Source: Genomics Data - July 18, 2016 Category: Genetics & Stem Cells Source Type: research