Enzymatic reduction of α-substituted ketones with concomitant dynamic kinetic resolution

Publication date: Available online 18 July 2016 Source:Journal of Molecular Catalysis B: Enzymatic Author(s): Ronald L. Hanson, Zhiwei Guo, Francisco González-Bobes, Michaël D.B. Fenster, Animesh Goswami Racemic α-substituted ketones were converted to the corresponding chiral alcohols with high diastereo- and enantioselectivities using enzymatic reduction with concomitant dynamic kinetic resolution. Reductions of N-protected α-amino ketones by microorganisms and commercial enzymes provided N-protected α-amino alcohols. Choice of buffer was found to be a crucial factor for the successful reduction and simultaneous dynamic resolution of an α-methyl ketone to the corresponding chiral alcohol. Graphical abstract
Source: Journal of Molecular Catalysis B: Enzymatic - Category: Biochemistry Source Type: research