Pro‐toxic 1,2‐Dehydropyrrolizidine Alkaloid Esters, Including Unprecedented 10‐Membered Macrocyclic Diesters, in the Medicinally‐used Alafia cf. caudata and Amphineurion marginatum (Apocynaceae: Apocynoideae: Nerieae and Apocyneae)

ConclusionsThe presence of pro‐toxic dehydropyrrolizidine alkaloids suggests that medical preparations of these plants pose potential health risks to consumers. Dehydropyrrolizidine alkaloids are evidently more widespread in Apocynoideae than previously assumed, and it would seem rewarding to study other members of this family for the presence of pyrrolizidines, dehydropyrrolizidines and dihydropyrrolizines. Copyright © 2016 John Wiley & Sons, Ltd.

Source: Phytochemical Analysis - April 30, 2016 Category: Biochemistry Authors: Steven M. Colegate, Dale R. Gardner, Joseph M. Betz, Ottmar W. Fischer, Sigrid Liede‐Schumann, Michael Boppré Tags: Research Article Source Type: research