Pharmacokinetics and pharmacodynamics of intravenous romifidine and propranolol administered alone or in combination for equine sedation

Conclusions and clinical relevanceAlthough not associated with reduced behavioral responsiveness or sedation alone, propranolol augmented romifidine sedation, probably through alterations in romifidine pharmacokinetics, in horses administered PR. The occurrence of severe bradycardia warrants caution in the co‐administration of these drugs at the doses studied.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fvaa.12410

Source: Veterinary Anaesthesia and Analgesia - June 30, 2016 Category: Veterinary Research Authors: Alessia Cenani, Robert J Brosnan, Shara Madigan, Heather K Knych, John E Madigan Tags: Research Paper Source Type: research