Procalcitonin in Critically Ill Patients: ProGUARD study results

This article was published in the November 15, 2014 issue of the American Journal of Respiratory and Critical Care Medicine. One of the challenges in bringing this test online is determining an appropriate cut-off value for "rule-out." The authors report their results using an algorithm with a low cut-off but show that it did not achieve the desired endpoint of reducing antibiotic duration.  The study did show, however, that the decline rate in log(PCT) over the first 72 hours independently predicted hospital and 90-day mortality. In a personal communication with the lead author, Dr. Shehabi confirmed that this lower cut-off was used across different commercially available test methods (including the one we are using) that were used at the different participating centers. If you are using or plan to implement procalcitonin in your facility, I highly suggest you review this paper.
Source: The Daily Sign-Out - Category: Cancer & Oncology Authors: Tags: Biomarkers in Disease Source Type: blogs