Expression of Progesterone Receptor in the Porcine Uterus and Placenta throughout Gestation: Correlation with Expression of Uteroferrin and Osteopontin

Progesterone (P4) stimulates production and secretion of histotroph, a mixture of hormones, growth factors, nutrients, and other substances required for growth and development of the conceptus (embryo/fetus and placental membranes). Progesterone acts through the progesterone receptor (PGR); however, there is a gap in our understanding of P4 during pregnancy because PGR have not been localized in the uteri and placentae of pigs beyond Day 18. Therefore, we determined endometrial expression of PGR mRNA and localized PGR protein in uterine/placental tissues throughout the estrous cycle and through Day 85 of pregnancy in pigs.
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research