Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis [Neurooncology]
Conclusion
The most impactful biomarker for posterior fossa ependymoma is molecular subgroup affiliation, independent of other demographic or treatment variables. However, both EPN_PFA and EPN_PFB still benefit from increased extent of resection, with the survival rates being particularly poor for subtotally resected EPN_PFA, even with adjuvant radiation therapy. Patients with EPN_PFB who undergo gross total resection are at lower risk for relapse and should be considered for inclusion in a randomized clinical trial of observation alone with radiation reserved for those who experience recurrence.
Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Ramaswamy, Hielscher, Mack, Lassaletta, Lin, Pajtler, Jones, Luu, Cavalli, Aldape, Remke, Mynarek, Rutkowski, Gururangan, McLendon, Lipp, Dunham, Hukin, Eisenstat, Fulton, van Landeghem, Santi, van Veelen, Van Meir, Osuka, Fan, Muraszko, Tirapelli, Oba-Sh Tags: Brain Tumors, Surgery, Radiation, Translational Oncology, CNS Tumors, Gene Expression and Profiling Neurooncology Source Type: research
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